Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2876-80. doi: 10.1016/j.bmcl.2005.03.089.

Abstract

Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)'s as low as around 100 nM were achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Excitatory Amino Acid Antagonists / chemistry
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Excitatory Amino Acid Antagonists
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate